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Clinical Trials

Title Start Date Principal Name
A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with BCG-Unresponsive High Grade Non-Muscle Invasive Bladder Cancer (NMIBC)    
A Multicenter, Prospective, Randomized, Open-Label Study with a Crossover Extension Option to Evaluate the Safety and Efficacy of GrafixPLTM PRIME for the Treatment of Chronic Venous Leg Ulcers 09/01/2018  Scott Gorenstein, MD 
A New Paradigm for Vitamin D Sufficiency: A 6-month, randomized, double blind, placebo-controlled study to investigate vitamin D status in elderly Caucasian women   Jane S. Greensher, RN, MA, CCRC 
A Phase 1B/2 Study of Viagenpumatucel L (HS-110) in Combination with Multiple Treatment Regimens in Patients with Non Small Cell Lung Cancer (The "Durga" Trial) 10/10/2018  Jeffery Schneider, MD 
A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab versus Placebo in Subjects with High Risk Invasive Urothelial Carcinoma 02/06/2016  Mary O’Keeffe, MD 
A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer 11/14/2016  Mary O’Keeffe, MD 
A Pilot Study of Prostate Cancer-Specific Anxiety in Active Surveillance    
A Prospective, Multicenter, Randomized, Controlled Clinical Study Of PuraPly™ AM and Standard of Care (SOC) compared to SOC alone For The Management Of Stage II-IV Pressure Ulcers 05/09/2018  Scott Gorenstein, MD 
A Prospective, Single Arm, Longitudinal Cohort Study To Assess Biomarkers In Real World Patients With Severe Asthma   Marcella Aquino, MD 
A Randomized Phase 2 Trial of AM0010 in Combination With Nivolumab vs. Nivolumab Alone as Second-Line Therapy in Subjects With Stage IV / Metastatic Wild Type Non-Small Cell Lung Cancer and Low Tumor Expression of PD-L1 (Cypress 2) 12/26/2017  Jeffery Schneider, MD 
A Randomized Phase 2 Trial of AM0010 in Combination with Pembrolizumab vs. Pembrolizumab Alone as First-line Therapy in Patients with Metastatic Non-Small Cell Lung Cancer Whose Tumors Have High PD-L1 Expression (CYPRESS 1) 12/26/2017  Jeffery Schneider, MD 
A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen 02/28/2017  Alexander Hindenburg, MD 
A Randomized Study of Enzalutamide in Patients with Localized Prostate Cancer Undergoing Active Surveillance (ENACT)    
A Randomized, Double-blind, Placebo-controlled Phase 2 Study Comparing CB-839 in Combination with Cabozantinib (CB-CABO) vs. Placebo with Cabozantinib (Pbo-Cabo) in Patients with Advanced or Metastatic Renal Cell Carcinoma (RCC) 03/27/2018  Mary O’Keeffe, MD 
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study Comparing CB-839 in Combination with Everolimus (CBE) vs. Placebo with Everolimus (PboE) in Patients with Advanced or Metastatic Renal Cell Carcinoma (RCC)   Mary O’Keeffe, MD 
A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effectiveness of a Nutritional Intervention in Improving the Intestinal Mucosal Health Status in Subjects with Crohn’s Disease (CD) Receiving Anti-TNF Therapy (PIONEER-CD) 06/01/2017  Raluca Vrabie, MD 
A Randomized, Multicenter, Phase 2 Study of DSP- 7888 Dosing Emulsion in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma following Initial Therapy 03/29/2017  Dr. Paul Duic 
A randomized, open-label, multicenter, phase 3 study to evaluate the efficacy and safety of avelumab in combination with chemotherapy followed by maintenance therapy of avelumab in combination with... 10/18/2018  Eva Chalas, MD 
A Study of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with BCG-Naïve Non-Muscle Invasive Bladder Cancer (NMIBC)    
A Study of Nivolumab in Combination with Ipilimumab (part 1); and Nivolumab plus Ipilimumab in Combination with Chemotherapy vs. Chemotherapy alone (part 2) as First Line Therapy in stage IV Non-Small Cell Lung Cancer (NSCLC) 06/02/2016  Jeffery Schneider, MD 
ALLIANCE 011502: A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2 Negative Breast Cancer: The ABC Trial 08/01/2017  Nina D’Abreo, MD 
Alliance A011401: Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer: BWEL Breast Cancer Weight Loss Study 08/29/2016  Nina D’Abreo, MD 
Antithrombotic Strategy Variability In ATrial Fibrillation and Obstructive Coronary Disease Revascularized with PCI. (AVIATOR 2 Registry)   Kevin Marzo, MD 
Asthma Study   Marcella Aquino, MD 
Bladder Cancer Quality of Life (QoL) Database    
Breast Milk Protein Intolerance and Maternal Dairy Consumption   Dr. Farrah Lazare, DO 
Bronchiectasis Clinical Research   Jonathan Ilowite, MD 
Cardiovascular Inflammation Reduction Trial (CIRT)   Joshua DeLeon, MD 
Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Primary PCI for STEMI (COMPLETE)   Srihari Naidu, MD 
Development of an Evidenced-Based Tool for Prediction of Sudden Death in Patients with Non-Ischemic Cardiomyopathy - (NICM Registry)   Juan Gaztanaga, MD 
Evaluation of HbA1c in Oncology Patients Beginning Intravenous Treatment 04/26/2018  Eva Chalas, MD 
Examination of Intestinal Microbiome in Multiple Myeloma Patients   Marc Braunstein, MD, PhD 
Examination of Intestinal Microbiome in Multiple Myeloma Patients   Marc Braunstein, MD, PhD 
GEODE: Registry of Guardant360® Use and Outcomes in People with Advanced Cancer Including: Module 1: Non-Small Cell Lung Cancer (NSCLC) 06/22/2018  Jeffery Schneider, MD 
Gout Research Study   Gary Rosenblum, DO 
GraftMaster RX Coronary Stent Graft System (JOSTENT)   Kevin Marzo, MD 
IMPELLA RP® Circulatory Support System   Srihari Naidu, MD 
International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA)   Kevin Marzo, MD 
Investigating and Characterizing the Immune Response to Prostate Cancer Treatment    
MammaPrint, BluePrint, and Full-genome Data Linked with Clinical Data to Evaluate New Gene EXpression Profiles: An Adaptable Registry (FLEX Registry) 02/15/2017  Nina D’Abreo, MD 
Medical research study for people with Moderately to Severely Active Ulcerative Colitis   Raluca Vrabie, MD 
Metformin Prostate Cancer Adjuvant Trial    
Methotrexate and Cholesterol Transport Regulation: Impact of Treatment Regimen in Diabetes and Metabolic Syndrome CIRT Sub-Study   Joshua DeLeon, MD 
N1048: A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total... 01/13/2012  Prashanti Atluri, MD 
NRG-BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node Negative Triple-Negative Breast Cancer 09/24/2015  Nina D’Abreo, MD 
OBGYN: Chronic Hypertension and Pregnancy (CHAP)   Wendy Kinzler, MD 
ONT-380-206: Phase II Randomized, Double-Blinded, Controlled Study of Tucatinib vs. placebo in combination with Capecitabine and Trastuzumab in Patients with Pretreated Unresectable Locally Advanced or Metastatic HER2+ Breast Carcinoma 05/05/2017  Nina D’Abreo, MD 
PARTNER 3: A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients Requiring Aortic Valve Replacement Who Have Severe, Calcific, Symptomatic Aortic   Richard Schwartz, MD 
Patients diagnosed with Acute Hereditary Angioedema   Mark Davis-Lorton, MD 
Pediatric Meningococcal Vaccine   Leonard Krilov, MD 
PPCM (peripartum cardiomyopathy) Registry   Vijayapraveena Paruchuri 
Prader-Willi Syndrome Study   Moris A Angulo, MD 
Primary Progressive Multiple Sclerosis (MS)   Malcolm Gottesman, MD 
Prostate Cancer Quality of Life (QoL) Database    
PROTEGO DF4 Registry   Joseph Germano, DO 
R2222-RSV-1332;A Phase 3, Randomized, Double-blind, Placebo controlled Study Evaluating the Efficacy and Safety of a Human Monoclonal Antibody, REGN2222, for the Prevention of Medically Attended RSV Infection in Preterm Infants   Dr. Leonard R. Krilov, MD 
Rheumatoid Arthritis   Steven Carsons, MD 
S1416: Phase II Randomized Placebo-Controlled Trial of Cisplatin with or without ABT-888 (Veliparib) in Metastatic Triple Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer 09/08/2016  Nina D’Abreo, MD 
S1418/BR006: A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with = 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) after Neoadjuvan 02/02/2017  Nina D’Abreo, MD 
Safety of Calcium and Vitamin D Supplements at Institute of Medicine Upper Limits Recommendations, A Randomized, Controlled Trial 11/01/2017  John F. Aloia, MD 
SURTAVI: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement   Richard Schwartz, MD 
Tailored Anti-platelet Initiation to Lesson Outcomes Due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention (TAILOR-PCI)   Kevin Marzo, MD 
The Euro Observation Research Program, Registry of Pregnancy and Cardiac Disease (ROPAC)   Vijayapraveena Paruchuri 
The Global cVAD (ventricular assist device) Registry   Srihari Naidu, MD 
Use of Cytal® Wound Matrix and MicroMatrix® for the Management of Wounds 09/01/2018  Scott Gorenstein, MD