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CornerStone Vol. 28, No. 1, Winter/Spring 2018
Front page...

A "Bite of Hope" for Pediatric Diabetes Patients
New Star Room Designed Exclusively for Special Needs Children
An Outpouring of Support for the Cancer Center for Kids
Child Life Donations It Takes a Village
A Record Breaking Yuletide Ball
New Volunteer Birth-Doula Program is Born at NYU Winthrop
Internationally Acclaimed Pulmonary Rehab Program Celebrates 30 Years
NYU Winthrop Gala Raises More than $1,046,000 for Emergency Department Renovation Project
Hospital Celebrates the Dedication of the Stanley S. Zielony Neurosciences Wing
Athletic Trainers Help Student-Athletes Safely Spring into Sports
Distinguished Hospital Award for Clinical Excellence
NYU Winthrop Receives $4.2 Million NIH Grant to Study Neurocognitive Impact of Long Term Diabetes
At the Forefront of Lung Cancer Care: NYU Winthrop Leads the Way in the Area of Robotic Surgery
NYU Langone Health Brings Heart Transplant Services to NYU Winthrop
Annual Event is a Recipe for Success for One Local Foundation
Long Island’s First-Ever Ovarian Transplant Aims to Restore Fertility to Leukemia Survivor
Former NY Mets Star Infielder: Living with Prostate Cancer
The Naming of the David R. Doucette Clinical Research Center
The World's Smallest, Leadless Pacemaker Comes to NYU Winthrop
Stop the Bleed Prepares Communities to Respond to Terrorism Program aspires to save "countless lives"
Serving those who Served NYU Winthrop for Veterans Program
Have You Heard About the Grateful Patients and Families Program?
Once Again, Hospital Recognized for Meritorious Patient Outcomes by ACS

NYU Winthrop Receives $4.2 Million NIH Grant to Study Neurocognitive Impact of Long Term Diabetes

Alan M. Jacobson, MD, Chief Research Officer at NYU Winthrop | NYU Winthrop Hospital

Alan M. Jacobson, MD, Chief Research Officer at NYU Winthrop

Type 1 diabetes mellitus (T1DM) affects over 1,250,000 Americans who are at risk of developing microvascular and cardiovascular complications that are a major cause of morbidity, mortality and healthcare costs. As the regional leader in the diabetes care, NYU Winthrop Hospital is also committed to research endeavors to better understand and confront the devastating effects of the condition.

Recently, Alan M. Jacobson, MD, Chief Research Officer at NYU Winthrop Hospital, received a five-year grant from the National Institute of Health (NIH), totaling $4,232,222, to study the long-term neurocognitive impact of type 1 diabetes on individuals with the condition. The grant, entitled “The Effects of Biomedical Risk Factors on Neuro-cognition Using MRI: Long term follow-up of the Diabetes Control & Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Cohort,” will run through 2022.  The purpose of the grant is to determine the long term impact of type 1 diabetes on brain function.

As part of the Epidemiology of Diabetes Interventions & Complications (EDIC) study, which has followed individuals who have had diabetes for over 30 years to determine how standard versus intensive therapy affects complications from diabetes, this study will examine the important and unresolved questions about the frequency and causes of brain structure and thinking process problems using magnetic resonance imaging (MRI) techniques and cognitive testing.

“NYU Winthrop Hospital has made a major commitment to the expansion of research on the causes and consequences of diabetes,” said Dr. Jacobson, Principal Investigator of the study. “This research has strong connections to other areas of clinical care and investigations being carried out here. I am very enthusiastic about this opportunity to apply my three decades of research experience to NYU Winthrop’s ambitious research mission, which is focused on some of today’s most urgent healthcare challenges.”

The grant will allow Dr. Jacobson and his colleagues to study the effects of type 1 diabetes on brain structure and thinking processes, especially among the growing population of older patients who are at greatest risk for these potential complications. The study will allow an unparalleled opportunity to use blood sugar control and other information gathered over a 30 year period from early in the course of illness, among this group of patients to examine important and unresolved questions about the frequency and causes of these problems using magnetic resonance imaging (MRI) techniques and cognitive testing. 

By achieving these aims, Dr. Jacobson and his fellow researchers will determine key predictors of neurocognitive impairments and guide strategies to mitigate this risk, and address a topic of considerable concern, for which little definitive information is available to clinicians and patients, particularly those with long-standing type 1 diabetes who are over 50 years of age.

“Patients have increasing concerns about the extent to which diabetes can influence cognitive ability and brain functioning as they enter the age of greatest risk for impairment,” said Dr. Jacobson. “This study can help determine whether these effects occur and help identify modifiable risk factors that can be addressed by proper treatment.”

For more than a century, NYU Winthrop Hospital’s culture has been shaped by an ever-deepening commitment to integrating the highest quality patient care services with dynamic medical education programs and rigorous research initiatives. For more information about research endeavors at NYU Winthrop Hospital, visit